Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene42059482421600134234361642176447421845994217079942174522421614524216395342169055421692444216117542161324421889354218908442201549
Basic Information
VIS ID
TVIS44010535
Fusion event
HTLV-1-TCF20 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42597555/42201549 (Hg38)
End
42597555/42201549 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
TCF20
miRNAs that regulate target gene
hsa-mir-149-5p ; hsa-mir-205-5p ; hsa-mir-1247-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-433-3p ; hsa-mir-7154-5p ; hsa-mir-623 ; hsa-mir-6780b-3p ; hsa-mir-4780 ; hsa-mir-6729-3p ; hsa-mir-6847-5p ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-1178-5p ; hsa-mir-4779
Nearest miRNA
hsa-mir-1281/Upstream/278252; hsa-let-7a-3/Downstream/2999405;
Nearest TSS
ENST00000624155/Upstream/61622; ENST00000332965/Downstream/8659;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/48352, chr22-CpG: 180/Downstream/67897
Upstream sequence
GACATGTTAAAAAGTTTACTTAAAAAAACAACTTTAgaccaggcgcggtggctcatgcctgtaatcccaacacttcgggaggctgaggcagacggatcag
Downstream sequence
ttgaggtcaggagttcgagatcagcctcgccaacatggtgaaaccccgtctctactaaaaatacaaaaattagccaggcatggtggcaggtgcctgcaac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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