Basic Information
VIS ID
TVIS44010553
Fusion event
HTLV-1-DYNC2H1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
102988712/103117983 (Hg38)
End
102988712/103117983 (Hg38)
Orient
+
Location type
Intronic
Target gene
DYNC2H1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-331-3p ; hsa-mir-125b-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-10392/Upstream/1598078; hsa-let-7a-2/Downstream/731923;
Nearest TSS
ENST00000527297/Upstream/8408; ENST00000533027/Downstream/86928;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/25663, chr11-CpG: 43/Downstream/918694
Upstream sequence
ATCTTTGTCTTTAAATGTAAAGTGTATCTTCACTTGTTTGTAAATGTATTTTATAATCAATAAGCACTATACATCTGCTGGAAATTAGTTTTGTGAGAGA
Downstream sequence
ATAGGAATTAAAGTTCTTGTTGGGCCAGTTTCTACATCCTTTCTTTTTATTTTGTGTGAGACTGGTCAACTTGATAGTTGTGAGCTTATATTTTGTTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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