VISDB - VIS Detail

Basic Information

VIS ID

TVIS44010558

Fusion event

HTLV-1-MYO5A integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr15

Cytoband

q21.2

Reference genome

GRCh37/hg19

Start

52778274/52486077 (Hg38)

End

52778274/52486077 (Hg38)

Orient

Location type

Intronic

Target gene

MYO5A

miRNAs that regulate target gene

hsa-mir-103a-3p ; hsa-mir-32-5p ; hsa-mir-16-5p ; hsa-mir-145-5p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-3934-3p ; hsa-mir-4645-3p ; hsa-mir-7852-3p ; hsa-mir-3668 ; hsa-mir-646 ; hsa-mir-144-3p ; hsa-mir-3662 ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-6131 ; hsa-mir-3663-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-649 ; hsa-mir-490-3p ; hsa-mir-6756-3p ; hsa-mir-6868-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-3124-3p ; hsa-mir-4685-3p ; hsa-mir-3667-3p ; hsa-mir-4287 ; hsa-mir-6734-3p ; hsa-mir-5088-3p ; hsa-mir-6884-3p ; hsa-mir-1303 ; hsa-mir-642a-5p ; hsa-mir-1470 ; hsa-mir-4667-3p ; hsa-mir-141-5p ; hsa-mir-4733-5p ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-4795-5p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-5195-5p ; hsa-mir-500a-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-223-5p ; hsa-mir-297 ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-511-3p ; hsa-mir-567 ; hsa-mir-574-5p ; hsa-mir-6747-5p ; hsa-mir-6752-5p ; hsa-mir-6842-5p ; hsa-mir-6867-5p ; hsa-mir-7110-5p

Nearest miRNA

hsa-mir-10393/Upstream/208877; hsa-mir-11181/Downstream/2886863;

Nearest TSS

ENST00000557528/Upstream/60110; ENST00000566344/Downstream/42764;

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/190102, chr15-CpG: 119/Downstream/42059

Upstream sequence

ACAAGCAGTCATGAGGGCACAGTTCTGAAACCCACATTTCCATAGTAAACGTTTTCATTTTTATGAACTGTTTAAATCACATTCCTCTTCTATACTTTTC

Downstream sequence

CTATTCATTTTCAAATCAAattccaattcaacacgtatttaccaagtccctcttacaagcgaggttctgcgttaagctgggggtgggggatggtgaaaca

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.