Basic Information
VIS ID
TVIS44010563
Fusion event
HTLV-1-DGKE integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q22
Reference genome
GRCh37/hg19
Start
54941800/56864439 (Hg38)
End
54941800/56864439 (Hg38)
Orient
-
Location type
UTR3
Target gene
DGKE
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-6807-5p ; hsa-mir-1306-5p ; hsa-mir-556-5p ; hsa-mir-744-3p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-455-3p ; hsa-mir-7641 ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-3194-3p ; hsa-mir-4695-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-3607-5p ; hsa-mir-572 ; hsa-mir-1304-3p ; hsa-mir-6890-3p ; hsa-mir-433-3p ; hsa-mir-7154-5p ; hsa-mir-4530 ; hsa-mir-922 ; hsa-mir-6858-3p ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-3199 ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-4258 ; hsa-mir-4707-3p ; hsa-mir-4740-3p ; hsa-mir-552-3p ; hsa-mir-764 ; hsa-mir-8052
Nearest miRNA
hsa-mir-10226/Upstream/6095709; hsa-mir-1250/Downstream/26831;
Nearest TSS
ENST00000595228/Upstream/2253; ENST00000574826/Downstream/24441;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/29330, chr17-CpG: 89/Downstream/49032
Upstream sequence
atccatgaattgccataaacctAAGTTTGCCTCACCTCAGGCCCAGACCATGTTTTCAAAGAGCAACTTAGTAATGTATACAGTAGTCAGTACATTTTAT
Downstream sequence
GAAATACTCTATTTTGCTAAATTAACCTCTTGCAGATCTCCTCAGGTGATCTTAAATTCTAGTCTTGAGAAACTTTGTGAGCAGATCTGTTTTCAGCTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate