Basic Information
VIS ID
TVIS44010564
Fusion event
HTLV-1-DDX42 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
61857685/63780325 (Hg38)
End
61857685/63780325 (Hg38)
Orient
-
Location type
Intronic
Target gene
DDX42
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-615-3p ; hsa-mir-345-5p ; hsa-mir-186-5p ; hsa-mir-10a-5p ; hsa-mir-99a-5p ; hsa-mir-6867-3p ; hsa-mir-670-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6734-3p ; hsa-mir-5088-3p ; hsa-mir-6752-3p ; hsa-mir-1324
Nearest miRNA
hsa-mir-10226/Upstream/836013; hsa-mir-1250/Downstream/720449;
Nearest TSS
ENST00000595228/Upstream/3974; ENST00000580108/Downstream/6711;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/5623, chr17-CpG: 56/Downstream/47041
Upstream sequence
gcggaggttgtggtgagctgagattgcgccattgcactccagcctgggcaacaagagcgaaactgtctcaaaaaaacaaaaaaaaaaaaaaGTAGGAAAA
Downstream sequence
ACTGTTGTCAAGAGACTTAAGTAATGATCCATTGAGGATGATCTGGCTTAGATTTAATCAGGAAGGGTGGTTAGCTAGATAACAAGGTTTGTAGTAATAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate