Basic Information
VIS ID
TVIS44010574
Fusion event
HTLV-1-JAKMIP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37/hg19
Start
147155166/147775603 (Hg38)
End
147155166/147775603 (Hg38)
Orient
+
Location type
Intronic
Target gene
JAKMIP2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-103a-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-4307 ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-8068 ; hsa-mir-6867-5p ; hsa-mir-1229-3p ; hsa-mir-1273f ; hsa-mir-129-5p ; hsa-mir-143-3p ; hsa-mir-223-5p ; hsa-mir-4708-5p ; hsa-mir-4770 ; hsa-mir-4778-5p ; hsa-mir-5096 ; hsa-mir-6088 ; hsa-mir-630 ; hsa-mir-6511a-3p ; hsa-mir-6511b-3p ; hsa-mir-6784-3p ; hsa-mir-6862-3p ; hsa-mir-8055
Nearest miRNA
hsa-mir-10397/Upstream/4095632; hsa-mir-103a-1/Downstream/1286710;
Nearest TSS
ENST00000502646/Upstream/114157; ENST00000504320/Downstream/6939;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/265438, chr5-CpG: 33/Downstream/608117
Upstream sequence
TTAAAAGAAAATAAAAAGATCCACGGAAGTGTTCATAATCTTTCTTACTTATATTGTAGCATGTAGTGAGCAGTCTTTAATGATGGATTGTTAAGTGTTA
Downstream sequence
TGATATATTACCTTTAAGAATATGATTTTGCCTTATCAAAATCATAACATCCTGAGGATGTGAATGCAATTCATTTTGTTTTTACAGTCAAATTAAAAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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