Basic Information
VIS ID
TVIS44010579
Fusion event
HTLV-1-TMEM196 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
19790091/19750468 (Hg38)
End
19790091/19750468 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM196
miRNAs that regulate target gene
hsa-mir-491-3p ; hsa-mir-1273e ; hsa-mir-4753-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-130b-5p ; hsa-mir-329-5p ; hsa-mir-3184-3p ; hsa-mir-6750-3p ; hsa-mir-3662 ; hsa-mir-767-5p ; hsa-mir-3613-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-630 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-520f-5p
Nearest miRNA
hsa-mir-1302-6/Upstream/45032; hsa-mir-10399/Downstream/1720590;
Nearest TSS
ENST00000635602/Upstream/41381; ENST00000590912/Downstream/22726;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/41230, chr7-CpG: 138/Downstream/579912
Upstream sequence
atgaaaCTAcaatgcaaatgaataaattggaagacctttttctgttagtcagaagaggattttttttttagcaaatttccaagtagttgaggtatttaat
Downstream sequence
cattattatgtcctTACACATATTCGTATCTCACAAGAACTCCTTAACACATGTCAGCCTTAAGCTGGTGAAAAGTTGCTCTGGGGTTGTAAATACTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate