Basic Information
VIS ID
TVIS44010586
Fusion event
HTLV-1-SEL1L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
81942425/81476081 (Hg38)
End
81942425/81476081 (Hg38)
Orient
+
Location type
UTR3
Target gene
SEL1L
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-4668-5p ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-1260a/Upstream/4209791; hsa-mir-1185-1/Downstream/12472145;
Nearest TSS
ENST00000550708/Upstream/25924; ENST00000554814/Downstream/8447;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/39278, chr14-CpG: 52/Downstream/57326
Upstream sequence
TTTCATATTTAAAGAATTCAGGAAGGTGATGTGTTCTTTGTGCAAAAAGAAATGCAAAGTAAAATAAATCCTGGGAACAAATGCTTCAACTTTAGGAAAA
Downstream sequence
GTATGTCTGTGTCTGTGATCGTAGTACCCCAACCAGAGTTCGTTTTGTTTTCTAATTTCTCCCACTTAGTCCATCCTCTGGCTTCTGGATCAAGGCTCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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