Basic Information
VIS ID
TVIS44010605
Fusion event
HTLV-1-LPIN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
11906635/11766509 (Hg38)
End
11906635/11766509 (Hg38)
Orient
+
Location type
Intronic
Target gene
LPIN1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-92a-3p ; hsa-mir-17-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-485-5p ; hsa-mir-432-3p ; hsa-mir-122-5p ; hsa-mir-1289 ; hsa-mir-129-5p ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4802-3p ; hsa-mir-489-3p ; hsa-mir-514a-3p ; hsa-mir-514b-3p ; hsa-mir-6514-5p
Nearest miRNA
hsa-mir-4261/Upstream/225832; hsa-mir-10b/Downstream/935;
Nearest TSS
ENST00000437798/Upstream/19871; ENST00000460096/Downstream/10698;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/19428, chr2-CpG: 29/Downstream/18348
Upstream sequence
ggccaattctgacaggctgggaagtgtagcctcctgccagaagcagaaacagacactttgaggaaggggcaaagagaccagggatttgtgctgtctgggg
Downstream sequence
tcacagaatctacatatttaataagccacaggagaggtcgtgagtgttcaggagaggaaaacatgcacacgtgcaactgagcttctgcctgtccatggga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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