Basic Information
VIS ID
TVIS44010607
Fusion event
HTLV-1-ATRNL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
117381213/115621703 (Hg38)
End
117381213/115621703 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ATRNL1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-379-3p ; hsa-mir-3613-3p ; hsa-mir-3163 ; hsa-mir-577 ; hsa-mir-6771-3p ; hsa-mir-4282 ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-107/Upstream/1447524; hsa-mir-202/Downstream/1205785;
Nearest TSS
ENST00000439456/Upstream/154529; ENST00000449616/Downstream/287648;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/527368, chr10-CpG: 18/Downstream/503599
Upstream sequence
gctctgattttttttgtgtaatttcctcatcagtttaaaaatgtgtacaagaatgtgctataatatagccctcctagaatccctgaaagaaggttgttct
Downstream sequence
ggaatgccattagaacttGAAGATCCCATTCCATTTCTTATTAATCTTTCAGAGCAAAGAAAATCATTTTCCCTGCTGTATGAAATTTAAAGTGTATACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate