Basic Information
VIS ID
TVIS44010609
Fusion event
HTLV-1-TBC1D2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
101008616/98246334 (Hg38)
End
101008616/98246334 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBC1D2
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-17-5p
Nearest miRNA
hsa-let-7a-1/Upstream/17117; hsa-mir-12126/Downstream/8354594;
Nearest TSS
ENST00000422679/Upstream/17251; ENST00000610463/Downstream/9246;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/53451, chr9-CpG: 96/Downstream/8766
Upstream sequence
CTGGGAGACTGAAACATTTAGgagcggagatttgtttttgcactatatctgcaaaaagggtgtgggtataaaaatattaaatataatgatgggggtcagg
Downstream sequence
gggagctgttcaacctacctaagaaaagaaactTAGCAGTAGTTCAAACAACAGACAGTGTATTTGTAAATTCCTAACAGGCTCCATCAGATCTGGCAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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