VISDB - VIS Detail

Basic Information

VIS ID

TVIS44010626

Fusion event

HTLV-1-G2E3 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr14

Cytoband

q12

Reference genome

GRCh37/hg19

Start

31085645/30616439 (Hg38)

End

31085645/30616439 (Hg38)

Orient

Location type

Exonic

Target gene

G2E3

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-186-5p ; hsa-mir-125a-5p ; hsa-let-7a-5p ; hsa-mir-9-3p ; hsa-mir-548v ; hsa-mir-548au-3p ; hsa-mir-6509-5p ; hsa-mir-511-5p ; hsa-mir-5701 ; hsa-mir-331-5p ; hsa-mir-585-5p ; hsa-mir-5682 ; hsa-mir-6830-3p ; hsa-mir-582-5p ; hsa-mir-5681b ; hsa-mir-935 ; hsa-mir-4678 ; hsa-mir-5003-3p ; hsa-mir-6739-3p ; hsa-mir-375 ; hsa-mir-921 ; hsa-mir-3606-5p ; hsa-mir-8068 ; hsa-mir-3682-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-1272 ; hsa-mir-708-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac

Nearest miRNA

hsa-mir-208a/Upstream/2983161; hsa-mir-1185-1/Downstream/398207;

Nearest TSS

ENST00000550708/Upstream/5137; ENST00000556413/Downstream/5673;

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/56833, chr14-CpG: 122/Downstream/257710

Upstream sequence

CCTCCAGCTGGATTTAAACCCACTCCTTCAATTGAGTGTCTGCATGTGGATTTTCCTGTTGGAAACAAGTGTAATAACTGTTTAGCAATTCCCATCACCA

Downstream sequence

ATACATATAAAGAGTTTCAAGAAAATATGGACTTCACCATAAGAAACACTCTAAGACTAGAAAAGGAAGAAAGTTCTCATTACATTGGACATTAAAATGT

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.