Basic Information
VIS ID
TVIS44010631
Fusion event
HTLV-1-ZNF485 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
44104623/43609175 (Hg38)
End
44104623/43609175 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
ZNF485
miRNAs that regulate target gene
hsa-mir-378a-5p ; hsa-mir-1273e ; hsa-mir-1322 ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-6501-5p ; hsa-mir-4423-5p ; hsa-mir-143-5p ; hsa-mir-431-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-3135b ; hsa-mir-504-3p ; hsa-mir-31-3p ; hsa-mir-6499-3p ; hsa-mir-5693 ; hsa-mir-4717-3p ; hsa-mir-4781-3p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-1289 ; hsa-mir-924 ; hsa-mir-6514-5p ; hsa-mir-1303 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-1273f ; hsa-mir-374c-3p ; hsa-mir-7977 ; hsa-mir-4284 ; hsa-mir-2276-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-6890-3p
Nearest miRNA
hsa-mir-1265/Upstream/611494; hsa-mir-107/Downstream/1554839;
Nearest TSS
ENST00000439456/Upstream/2749; ENST00000453284/Downstream/19642;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2257, chr10-CpG: 87/Downstream/39233
Upstream sequence
TTCATGAGTTGGACATCCTGGGTGCCACCCTCTAGGCCTCTCTGACCTGTCCATGCTCATTGCAGATGCTCAAGTTGACACTGAGGTCTGGAGTGACTGC
Downstream sequence
TTGTGCTTGTAACCGCCATCACATTCCTTTTCATTCATTTTTTTTTTCTTCCTCTAAGATCCTTTTTCTTTATGAACAGGGCTTCTCTCTTCCAAACCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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