Basic Information
VIS ID
TVIS44010635
Fusion event
HTLV-1-ZC3H18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
88640424/88574016 (Hg38)
End
88640424/88574016 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZC3H18
miRNAs that regulate target gene
hsa-mir-1914-3p ; hsa-mir-29b-2-5p ; hsa-mir-93-3p ; hsa-mir-484 ; hsa-mir-18b-5p ; hsa-mir-106b-5p ; hsa-mir-218-5p ; hsa-mir-183-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-92a-3p ; hsa-mir-31-5p ; hsa-mir-18a-5p ; hsa-mir-17-5p ; hsa-let-7f-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-11401/Upstream/104985; hsa-mir-4722/Downstream/142262;
Nearest TSS
ENST00000527434/Upstream/3538; ENST00000568072/Downstream/12601;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/3091, chr16-CpG: 26/Downstream/49043
Upstream sequence
tgctggagagcaatgacacaatcttggctcactgcaacctccgcccccccgagttcaagcaattctcctgcctcagcctcccgagcagctgggattacag
Downstream sequence
atgcccaccaccatgcccagctaatgttttgtatatttagtagagacaaggtttcaccattttgaccgggcttgtcctgaactcctgacctcaggtgatc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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