Basic Information
VIS ID
TVIS44010642
Fusion event
HTLV-1-chrX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q27.2
Reference genome
GRCh37/hg19
Start
140867452/141779666 (Hg38)
End
140867452/141779666 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRAXD
Nearest miRNA
hsa-let-7f-2/Upstream/853435; hsa-mir-105-1/Downstream/4213084;
Nearest TSS
ENST00000429181/Upstream/80927; ENST00000483584/Downstream/58650;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/602446, chrX-CpG: 130/Downstream/1853928
Nearby gene
MAGEC3(+58650) ;
Upstream sequence
gctgtgagggtcaaataagataaatgcaaaaTTTGGTGTTATTATTAGAAGTAATAATGGTAAAATAGAATATTTCATATCATTTAAAGATTTTTTATAT
Downstream sequence
ATACTGAGGAAGGAATTTTTTTCATACTGTTTCAAAACATCAATTCTGTAGTGTTATAACTAATTTTATTAAATGAATCACTGGTACAAAGATCACATTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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