Basic Information
VIS ID
TVIS44010645
Fusion event
HTLV-1-DHX30 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
47889001/47847511 (Hg38)
End
47889001/47847511 (Hg38)
Orient
+
Location type
Exonic
Target gene
DHX30
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-93-3p ; hsa-mir-589-3p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-149-5p ; hsa-mir-15b-5p ; hsa-mir-92a-3p ; hsa-mir-16-5p ; hsa-mir-1260b
Nearest miRNA
hsa-mir-12127/Upstream/2985530; hsa-let-7g/Downstream/2044;
Nearest TSS
ENST00000440867/Upstream/2009; ENST00000474183/Downstream/266;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/851, chr3-CpG: 33/Downstream/2128
Upstream sequence
GCCCCAGGGCTCCTTTACAGGTGGGATCCTGTGCTTCCTGCCTGGGTGGCAGGAGATCAAAGGAGTGCAGCAGCGCCTCCAGGAGGCCCTGGGCATGCAC
Downstream sequence
GAGAGCAAGTACCTCATCCTGCCAGGTGAGAGCCCCGGCGGAGGGACCAGGGACCTTTGGAAACCAGCCTGACCTCTGTCCTAGGGACTGACCCAACTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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