Basic Information
VIS ID
TVIS44010649
Fusion event
HTLV-1-ANAPC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
112640959/111883382 (Hg38)
End
112640959/111883382 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
ANAPC1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-100-5p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-4668-3p ; hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-1226-5p ; hsa-mir-4279 ; hsa-mir-6868-3p ; hsa-mir-4721 ; hsa-mir-3616-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-1266-3p ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/112248; hsa-mir-10b/Downstream/1699577;
Nearest TSS
ENST00000437798/Upstream/2504; ENST00000473065/Downstream/799;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/658624, chr2-CpG: 63/Downstream/378
Nearest cancer related gene
ANAPC1(TSG, No orient, 0)
Upstream sequence
TTATGAAACTTTAGTTCTGCAATTTTATAATGTTATTTTCTTATAACTTTGAGAGAAAATTACAGAATTGTTAAAGAATTATCATTTTGTACCGATTAAT
Downstream sequence
GCCACATATTTAATACTTTTTCAGTACCCCAAACTTTTAGAAATGTTTTTACTTGTTAGGTGCAACATAAACAGCTACACGTAAAAATACTATTAAATTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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