VISDB - VIS Detail

Basic Information

VIS ID

TVIS44010653

Fusion event

HTLV-1-A2ML1 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr12

Cytoband

p13.31

Reference genome

GRCh37/hg19

Start

8987444/8834848 (Hg38)

End

8987444/8834848 (Hg38)

Orient

+

Location type

Intronic

Target gene

A2ML1

miRNAs that regulate target gene

hsa-mir-1304-5p ; hsa-mir-6765-5p ; hsa-mir-6087 ; hsa-mir-3197 ; hsa-mir-4772-3p ; hsa-mir-3925-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-1306-5p ; hsa-mir-1304-3p ; hsa-mir-6890-3p ; hsa-mir-6787-3p ; hsa-mir-6736-3p ; hsa-mir-216a-5p ; hsa-mir-891a-3p ; hsa-mir-5693

Nearest miRNA

hsa-mir-141/Upstream/1870657; hsa-let-7i/Downstream/404619;

Nearest TSS

ENST00000382841/Upstream/3901; ENST00000536789/Downstream/8388;

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/136041, chr12-CpG: 56/Downstream/79502

Upstream sequence

ACCTTGAAGACAGAAGCAACTCTGAGATCTTGGCCCAGAGCCCCATGACTCTGCCCAGCACCGAGCGCCCACATCCACCTAAGCTGTGCCTGCTTTCTTG

Downstream sequence

CCTCTGCCCTCCTAGTCTCTCACACCTACATTTCAGTAGACAAGGACACCAGCCTCTGTAATGACTACACCGCTCTCTCATTCCCCTAACTTCTCTGTGC

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.