Basic Information
VIS ID
TVIS44010656
Fusion event
HTLV-1-BCKDHB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
81031059/80321342 (Hg38)
End
81031059/80321342 (Hg38)
Orient
+
Location type
Intronic
Target gene
BCKDHB
miRNAs that regulate target gene
hsa-mir-1-3p
Nearest miRNA
hsa-mir-10398/Upstream/1782033; hsa-mir-1202/Downstream/9991400;
Nearest TSS
ENST00000381078/Upstream/118240; ENST00000491328/Downstream/22229;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/214373, chr6-CpG: 231/Downstream/1430074
Nearest cancer related gene
BCKDHB(OG, No orient, 0)
Upstream sequence
TAGGAGCAGTACACATTTTCCATCCTTAAGTATCTGGATGGGAAGAGATCTAGAGAACAGAATATCATATGTCTCCTGACTCATAACTTGGGATCTTTCC
Downstream sequence
TCAATTCTACTGAATAACCTGTAGTGGAAAACCATGTTTCTATAGTCCTATCCCTCGTCCAGGTGGATTATCTGAACAGGACTCCTGTGGAATGGTTGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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