Basic Information
VIS ID
TVIS44010658
Fusion event
HTLV-1-CADPS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q31.32
Reference genome
GRCh37/hg19
Start
121969945/122329891 (Hg38)
End
121969945/122329891 (Hg38)
Orient
+
Location type
Intronic
Target gene
CADPS2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-30c-5p ; hsa-mir-1256 ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-3127-3p ; hsa-mir-3679-3p ; hsa-mir-4262 ; hsa-mir-4642 ; hsa-mir-506-5p ; hsa-mir-5684 ; hsa-mir-6756-3p ; hsa-mir-6826-3p ; hsa-mir-6832-3p
Nearest miRNA
hsa-mir-10525/Upstream/5309572; hsa-mir-10399/Downstream/4728197;
Nearest TSS
ENST00000635602/Upstream/1399; ENST00000422260/Downstream/92111;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/12604, chr7-CpG: 120/Downstream/555803
Upstream sequence
CTTTAGACCCTCCAAGGCTGATATTCCTAAATCTGAATCACAAGACCACATAGGGTTTATATATCACGGCTGCTTCAAGCAAATGATTTTTGTCAGAATG
Downstream sequence
CGGCTTCTGATGATGATGGCAAGGTAAAAATAGCTGCTTCGCTAGGGCACAAATCTGTGATATATTTTCTACTTAAGTGTTTAGCTTTTTATTGATTATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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