Basic Information
VIS ID
TVIS44010661
Fusion event
HTLV-1-LRRC8A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
131655247/128892968 (Hg38)
End
131655247/128892968 (Hg38)
Orient
+
Location type
Intronic
Target gene
LRRC8A
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-33a-5p ; hsa-let-7b-5p ; hsa-mir-149-5p ; hsa-let-7e-5p ; hsa-mir-191-5p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-1250-3p ; hsa-mir-330-3p ; hsa-mir-6715a-3p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-4804-5p ; hsa-mir-184 ; hsa-mir-4719 ; hsa-mir-4694-3p
Nearest miRNA
hsa-let-7a-1/Upstream/500254; hsa-mir-12126/Downstream/976637;
Nearest TSS
ENST00000422679/Upstream/7973; ENST00000492784/Downstream/19776;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/10498, chr9-CpG: 80/Downstream/14635
Upstream sequence
TCCTGCTTGGGAAGTTTTCCTGGCTCAGCCTTGTTTGTGCTTTCACAAAAGGCTCTCTGTGCCCTGTTTACCCGCAGCCCGACTGCCTGCCGCCCAGGTG
Downstream sequence
TGGGAGCCACGCCAAATCCCTGTGGGCCCACATGGGGTCTGGTGCGTGCTGGGGGGGTCTCTCTCTGGGACAGAGTGGGCAGCTTGTCATTTCTTGACTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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