Basic Information
VIS ID
TVIS44010663
Fusion event
HTLV-1-B3GNT5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q27.1
Reference genome
GRCh37/hg19
Start
182974634/183256846 (Hg38)
End
182974634/183256846 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
B3GNT5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30b-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-10a-5p ; hsa-mir-30c-5p
Nearest miRNA
hsa-let-7g/Upstream/6741695; hsa-mir-1224/Downstream/629954;
Nearest TSS
ENST00000440867/Upstream/2221; ENST00000477699/Downstream/8400;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1999, chr3-CpG: 126/Downstream/170793
Upstream sequence
CCTCAAGTTTCCTTCTCTTACTTTAGAGGACCATATAATCTTATACCTGTGTCATCCTAATTGAAATGTATTTTAAGTGCTTGTGGGAACAAGAATAACG
Downstream sequence
GAAGACCGTTATTCCATTAATGGAATAATGGGGAACATGAGAAGGACCATATTCAGTCAATTAGGGATGATACTTCTGCCTCAACAGTATTTGCGATGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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