Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene718708486959829670793495706932977069820070727860707301897069930370701486707096437071156170716655707183837071965270721237707036467070438770726742707273537070480170705104707063157070656470698315706984847073083570730968707130757071320470734572
Basic Information
VIS ID
TVIS44010680
Fusion event
HTLV-1-AUTS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
70199558/70734572 (Hg38)
End
70199558/70734572 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
AUTS2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-222-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1183/Upstream/3620175; hsa-mir-10399/Downstream/573100;
Nearest TSS
ENST00000635602/Upstream/5433; ENST00000483297/Downstream/28712;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/38871, chr7-CpG: 92/Downstream/55336
Upstream sequence
AATATTAGTATGGGGATACATTGTCCCCTCCCCCCTTTTTCTCTCAGTTAAAAATCTGTCCCAGAATGAGGTTTGGCGGGACATATGGTTTGGCGTGCTT
Downstream sequence
GTGGGGGCTGGCAGGGTGAGGTATGTATGGTAGTGTAGTTATCTGGCATCTTATCTGCTCACTGGAAATGTTGGGCACTGAATAGATTAGTCAGAGTTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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