Basic Information
VIS ID
TVIS44010688
Fusion event
HTLV-1-RNF220 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.1
Reference genome
GRCh37/hg19
Start
44877181/44411509 (Hg38)
End
44877181/44411509 (Hg38)
Orient
+
Location type
Intronic
Target gene
RNF220
miRNAs that regulate target gene
hsa-mir-93-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p
Nearest miRNA
hsa-mir-12136/Upstream/572826; hsa-mir-101-1/Downstream/133984;
Nearest TSS
ENST00000473358/Upstream/2807; ENST00000470498/Downstream/1189;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3134, chr1-CpG: 79/Downstream/5955
Upstream sequence
GCCAATGTGTATCTTTTATCCATGTGTATACTTTGTACTAACTAATATGTACAAGTGTTCCTGGTCTAGATGAACTTGAATTAGGGATATTTCAGTATCA
Downstream sequence
GGGTGTTGTTAGGGGAGATGAAGAGAGGATGCATATGTGGGGAATCGTATAGGTAGAATGTGGTCTCTGAACATCAGGCCTGCCATGAGTGGTGGATGCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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