Basic Information
VIS ID
TVIS44010696
Fusion event
HTLV-1-PARD3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
205813401/204948678 (Hg38)
End
205813401/204948678 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
PARD3B
miRNAs that regulate target gene
hsa-mir-6873-3p ; hsa-mir-3941 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6758-3p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3180-5p ; hsa-mir-4642 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-891a-3p ; hsa-mir-3688-5p ; hsa-mir-4267
Nearest miRNA
hsa-mir-10b/Upstream/15815567; hsa-mir-1244-1/Downstream/1834556;
Nearest TSS
ENST00000437798/Upstream/402678; ENST00000489565/Downstream/16474;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/402491, chr2-CpG: 91/Downstream/733201
Upstream sequence
GAACATGAGCATTAAAACAAAAAAAGGAACCTATTGTTCCAGCAGACTCTTCTCCAGTTCCCCAGTATTTATCTTACAGGGTTTTCTAAGTGCAATATCA
Downstream sequence
GGTGTTCACCATTGGTTGTCCGCACTCACTTTCTATTTTCCCTCTTGATTCAGAGAAATTATTTGTCTTAGTCCAATAAAAATAGGGCTTTTTCTTTTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate