Basic Information
VIS ID
TVIS44010704
Fusion event
HTLV-1-SPATA16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q26.31
Reference genome
GRCh37/hg19
Start
172671678/172953888 (Hg38)
End
172671678/172953888 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPATA16
Nearest miRNA
hsa-let-7g/Upstream/1847129; hsa-mir-1224/Downstream/2415652;
Nearest TSS
ENST00000440867/Upstream/135557; ENST00000447709/Downstream/187380;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/202833, chr3-CpG: 49/Downstream/441592
Upstream sequence
AGGGAGAAGAAAAACTCTTGAAAAGGAGAAGGAAGCTGGTGAATGTGGTTAGATAGGTTCTAAAGATAGATTAATTTTAGAAATGACTGGATTATACTGA
Downstream sequence
GTGCCCTGGGATGAGACAGAATATATTTTGGCTCTGGGCAGAGCAAAGAAGAAAATAGATAGGTAAAACATATAGACTCTTATGTTTGCACACATCTGCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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