Basic Information
VIS ID
TVIS44010713
Fusion event
HTLV-1-TMEM161B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
87531470/88235653 (Hg38)
End
87531470/88235653 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM161B
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-190a-3p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-101-5p ; hsa-mir-1244 ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-4446-5p ; hsa-mir-4307 ; hsa-mir-190b ; hsa-mir-190a-5p
Nearest miRNA
hsa-mir-10397/Upstream/1120699; hsa-mir-103a-1/Downstream/431200;
Nearest TSS
ENST00000502646/Upstream/15022; ENST00000504636/Downstream/15384;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/93965, chr5-CpG: 27/Downstream/33138
Upstream sequence
tccaccaggtggtgatacaagaagtaagcagtctgcaacctgagagagggtccttaccagaacctgaccatactagcatgctgacctcagacttccagcc
Downstream sequence
cccagaactgagaaatacatttctgctgttgagaagccatccagtctatggtactttgtaatagcagccctaacctactaaaacaGTCACTAATGACAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate