Basic Information
VIS ID
TVIS44010722
Fusion event
HTLV-1-NF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
29689439/31362421 (Hg38)
End
29689439/31362421 (Hg38)
Orient
+
Location type
Intronic
Target gene
NF1
miRNAs that regulate target gene
hsa-mir-10b-5p ; hsa-mir-370-3p ; hsa-mir-20a-3p ; hsa-mir-193b-3p ; hsa-let-7e-5p ; hsa-mir-9-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-193a-3p ; hsa-mir-374a-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-107 ; hsa-mir-514a-5p
Nearest miRNA
hsa-mir-1180/Upstream/267996; hsa-mir-10226/Downstream/172462;
Nearest TSS
ENST00000595228/Upstream/3873; ENST00000422121/Downstream/16227;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/16827, chr17-CpG: 118/Downstream/28791
Nearest cancer related gene
NF1(TSG, No orient, 0)
Upstream sequence
GCTGATAAACCTTTTAGCATTTTGGAGCTAGGGAACCATACAGGTAATTTAGTTTTAGGCTCACAATATTGTGTACATTGGGGAGACTGAGTTTTAGAAG
Downstream sequence
AGCTGGGTTAACTGCTTTATACAGTTCTTATCTAGAACCAAGGCCAGGCCCTTTTGTACTACATTCATTGCCTTCCATGGCTGTTGTCTGTTTGATTATC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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