Basic Information
VIS ID
TVIS44010729
Fusion event
HTLV-1-TOMM70 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
100101125/100382281 (Hg38)
End
100101125/100382281 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOMM70
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-342-3p ; hsa-mir-5698 ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-5693 ; hsa-mir-6499-3p ; hsa-mir-431-5p ; hsa-mir-193a-5p ; hsa-mir-7704 ; hsa-mir-615-5p ; hsa-mir-3665 ; hsa-mir-764 ; hsa-mir-6890-5p
Nearest miRNA
hsa-let-7g/Upstream/417883; hsa-mir-12124/Downstream/3141752;
Nearest TSS
ENST00000440867/Upstream/509; ENST00000466996/Downstream/18912;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/47172, chr3-CpG: 102/Downstream/18379
Upstream sequence
TTACCGTTTTAAATAAATAAGTTTTAAATAAAGTGGAAATAACACACCCAAAAGGCTCTCATAATGTATTTTGAATGCTTTATCTATAAAATTCAGCCCA
Downstream sequence
AAGAGTTTAATGGAAACATGCGATTTTTCATTTTATGTATAACAAATATCATTACTGTTATTTTGGTAATGTCTTCATATTTGAAGGAATAAAAAAAGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate