Basic Information
VIS ID
TVIS44010740
Fusion event
HTLV-1-NFIA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
61848279/61382607 (Hg38)
End
61848279/61382607 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
NFIA
miRNAs that regulate target gene
hsa-mir-424-5p ; hsa-mir-223-3p ; hsa-mir-107 ; hsa-mir-124-3p ; hsa-mir-193b-3p ; hsa-mir-100-5p ; hsa-mir-190a-3p ; hsa-mir-3924 ; hsa-mir-4496 ; hsa-mir-5011-5p ; hsa-mir-29a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-519d-5p ; hsa-mir-3145-5p ; hsa-mir-21-5p ; hsa-mir-181b-5p ; hsa-mir-382-5p ; hsa-mir-3662 ; hsa-mir-103a-3p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-6883-3p ; hsa-mir-335-3p ; hsa-mir-4662a-3p ; hsa-mir-4311 ; hsa-mir-302b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1649311; hsa-mir-101-1/Downstream/463468;
Nearest TSS
ENST00000473358/Upstream/30157; ENST00000493627/Downstream/21469;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/298857, chr1-CpG: 25/Downstream/271595
Upstream sequence
gccttccagttctttctctgtgcatagaaatagccttttcaatggtgtcatagtataacatcctattttgtaattgcctttttcaattaacattatatta
Downstream sequence
taaatgttttgccacatcattactcttttacagtattgcttacattggttataccatacttatttaaccagtccccaattgtagggcatttaagattttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate