Basic Information
VIS ID
TVIS44010744
Fusion event
HTLV-1-PREX2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
68893116/67980881 (Hg38)
End
68893116/67980881 (Hg38)
Orient
+
Location type
Intronic
Target gene
PREX2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-338-3p ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-219b-5p ; hsa-mir-3190-5p ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p
Nearest miRNA
hsa-mir-124-1/Upstream/3601624; hsa-mir-10400/Downstream/6567662;
Nearest TSS
ENST00000518652/Upstream/28392; ENST00000522247/Downstream/114200;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/28170, chr8-CpG: 75/Downstream/349804
Upstream sequence
gctgctatgtgaagaaggacctgtttgctttgccttctgtcatgatcgtaagtttcctgaggcctcctcagccatgctgaactgtgagtcagttaagcct
Downstream sequence
gtttccttttaaattactcagtcttgggtatttcttcatagcagtgtgagaatggactaatacaACTGCGCGTGGCTTTCTTCATCACTTTGTCCATTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate