Basic Information
VIS ID
TVIS44010750
Fusion event
HTLV-1-PI4K2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
99421269/97661512 (Hg38)
End
99421269/97661512 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
PI4K2A
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-877-5p ; hsa-mir-3124-3p ; hsa-mir-6844 ; hsa-mir-4540 ; hsa-mir-6832-3p ; hsa-mir-483-3p ; hsa-mir-6838-3p ; hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-107/Upstream/832748; hsa-mir-1287/Downstream/214301;
Nearest TSS
ENST00000439456/Upstream/20826; ENST00000451097/Downstream/25811;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/20287, chr10-CpG: 76/Downstream/25427
Upstream sequence
ccatcagtgtttggattaccccagttgtttcataaaaaaagatttttataattggcttgttgaaattatgatataaaggtccacatattacatttggtta
Downstream sequence
atatctttcctttctgttttttttttggagatgggatctcactatgttgcccaggctggtcttaaactcctgggctcaagcagtcctcccacctcagcct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate