Basic Information
VIS ID
TVIS44010758
Fusion event
HTLV-1-chr1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
26929521/26603030 (Hg38)
End
26929521/26603030 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1A
Nearest miRNA
hsa-mir-12136/Upstream/48437; hsa-mir-101-1/Downstream/4136126;
Nearest TSS
ENST00000473358/Upstream/30760; ENST00000524572/Downstream/90206;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/72837, chr1-CpG: 119/Downstream/17323
Nearby gene
RPS6KA1(+28001) ;
Upstream sequence
TCTCACCCAGGGGATTTTAAAAGCCAATCCCACCTCCTCCCCACAGTCCTCTCCTCTAACGCTCATTTCCCATCGCCTCACAAAATTGCCAGGGTAATTG
Downstream sequence
ACTCTTAGATGAGATGAGTTTGACTTTCTACCCTGATTTTGTAACAGAAGTTCTTTTGGTGAGGTTCTTTGTTTGAAAATGCACAATAAAAATGGCTTTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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