Basic Information
VIS ID
TVIS44010761
Fusion event
HTLV-1-ZSWIM5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.1
Reference genome
GRCh37/hg19
Start
45483707/45018035 (Hg38)
End
45483707/45018035 (Hg38)
Orient
-
Location type
UTR3
Target gene
ZSWIM5
miRNAs that regulate target gene
hsa-mir-205-5p ; hsa-mir-4287 ; hsa-mir-4325 ; hsa-mir-4469 ; hsa-mir-452-3p ; hsa-mir-4685-3p ; hsa-mir-4713-5p ; hsa-mir-4793-3p ; hsa-mir-629-3p ; hsa-mir-6500-3p ; hsa-mir-6752-3p ; hsa-mir-6867-3p ; hsa-mir-7113-3p ; hsa-mir-942-5p
Nearest miRNA
hsa-mir-12136/Upstream/472483; hsa-mir-101-1/Downstream/6041802;
Nearest TSS
ENST00000473358/Upstream/3488; ENST00000626198/Downstream/188521;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/6685, chr1-CpG: 150/Downstream/187632
Upstream sequence
CAAGGGAAACCTGAGAAATGGTTGTGAGTCTCCTCAGAAAATAAGCATATCCTCCTACCCACAGCTACTTCAAGTGCCCATCAAATCAGAAGCAGAATTA
Downstream sequence
TAAATAGTTACAAGTTTACAATAATTAGCAACACATATAGTATTTACAGTCCCACAAATGTGTCTGTTTCTCTGGTTAAGCAATCCCTGAGATGGAACAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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