Basic Information
VIS ID
TVIS44010810
Fusion event
HTLV-1-ATF3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
212785447/212612105 (Hg38)
End
212785447/212612105 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATF3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-331-3p ; hsa-mir-17-5p ; hsa-mir-494-3p ; hsa-mir-505-5p ; hsa-mir-30e-3p ; hsa-mir-30a-3p ; hsa-mir-24-3p ; hsa-mir-3180-5p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4291 ; hsa-mir-377-3p ; hsa-mir-4277 ; hsa-mir-4267 ; hsa-mir-584-3p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-216b-3p ; hsa-mir-5000-5p ; hsa-mir-3614-3p ; hsa-mir-1179 ; hsa-mir-590-5p ; hsa-mir-30c-2-3p
Nearest miRNA
hsa-mir-101-1/Upstream/534420; hsa-mir-1182/Downstream/7505748;
Nearest TSS
ENST00000473358/Upstream/3190; ENST00000336937/Downstream/1331;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/2361, chr1-CpG: 170/Downstream/87013
Nearest cancer related gene
ATF3(OG, No orient, 0)
Upstream sequence
CTTCATTTCCTTGTGGGGACACAGCCGTAGTCTAGGCTGAATCATACCTCGAGAGACTGAGTAAAGGAATAACTAGAAAGTATCCCGAGAAGTTAAGCTT
Downstream sequence
TAGCCTAGTGCCGAGAAAACCCAAATCTCGACAGATACATCTGTTTTATTTTCTGAAAGGCTTTTAACATTTTTACAACCATTTATGTCCCCAAGGAAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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