Basic Information
VIS ID
TVIS44010814
Fusion event
HTLV-1-ACBD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.12
Reference genome
GRCh37/hg19
Start
226353412/226165711 (Hg38)
End
226353412/226165711 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
ACBD3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-877-5p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-203b-3p ; hsa-mir-3606-5p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-7852-3p ; hsa-mir-6807-3p ; hsa-mir-3668 ; hsa-mir-217 ; hsa-mir-1273d
Nearest miRNA
hsa-mir-101-1/Upstream/243569; hsa-mir-1182/Downstream/1775879;
Nearest TSS
ENST00000473358/Upstream/4079; ENST00000542034/Downstream/21019;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/42936, chr1-CpG: 66/Downstream/20623
Upstream sequence
GAATCAAATGAAGCTCTACTTGTCTTATGTTCATAAGCAGATGAATACAGTTCTTCCACAATATTTAACCATAAACATCTCTAAGCTAAAAACAGATAAA
Downstream sequence
TATCTGAAGACTCCAGAAGCTGCAAGCAAAAATGTTCAGTTCTTATCCTAAGCTAATGAACCAGCTACTTACACCTTAACCAATACACATTGTACCCTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate