Basic Information
VIS ID
TVIS44010819
Fusion event
HTLV-1-FBH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
5946589/5904626 (Hg38)
End
5946589/5904626 (Hg38)
Orient
+
Location type
Intronic
Target gene
FBH1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-877-3p ; hsa-mir-374a-3p ; hsa-mir-361-3p ; hsa-mir-4286 ; hsa-mir-6729-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-3133
Nearest miRNA
hsa-mir-5699/Upstream/1913367; hsa-mir-107/Downstream/247570;
Nearest TSS
ENST00000439456/Upstream/1460; ENST00000494526/Downstream/1880;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/13952, chr10-CpG: 134/Downstream/72355
Upstream sequence
TGACTGTGGGTGTGACTGGATTCAACAGTTGGAAGATACCAGGATTTggctgggagcagtagctcatgccttatttgtaatcccagcagtttgggaggtt
Downstream sequence
gaagtgggagaattgcttgagcccagaagtgccagcccagcctgggcaacataatgagaccccgtctctattttaaaataataataatattttttaaaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate