Basic Information
VIS ID
TVIS44010828
Fusion event
HTLV-1-ANK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
62424264/60664506 (Hg38)
End
62424264/60664506 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
ANK3
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-8088 ; hsa-mir-598-5p ; hsa-mir-216b-3p ; hsa-mir-8485 ; hsa-mir-603 ; hsa-mir-503-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-1265/Upstream/3359947; hsa-mir-107/Downstream/2708451;
Nearest TSS
ENST00000439456/Upstream/91597; ENST00000517854/Downstream/68818;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/757470, chr10-CpG: 60/Downstream/68521
Upstream sequence
TATATGTGTGTACAAAGATAGCAGAGAACACTCCAGAAAGAAACATTTAATCAAATGAGTTGAGAATCGGTCACCTTGATACACCAGATGGTCCTATTGT
Downstream sequence
AAGCTTGTTTCATGCAAAGTTAGCCATTGAAAGTCTCAAAGCACAGAGAAACCAGAATAAATTAGCTCAAAACAAACCAATGCAGGCCAAAATGGTTAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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