Basic Information
VIS ID
TVIS44010845
Fusion event
HTLV-1-ANO3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
26547244/26525697 (Hg38)
End
26547244/26525697 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11D
Target gene
ANO3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-18a-3p ; hsa-mir-186-5p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-210/Upstream/3106507; hsa-let-7a-2/Downstream/989273;
Nearest TSS
ENST00000527297/Upstream/51795; ENST00000529242/Downstream/16248;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/193432, chr11-CpG: 29/Downstream/837375
Upstream sequence
TGTGGCTTTCCTTAGCTGTTTTCTATTATTTTTTCAGGAAAAAATGCTATTACACTGACGGGAGGAGCAAATCAATGGGCAGGTTGGTGGGTGATGAATC
Downstream sequence
ATTTCTTTATAACAAATTTGTCGTTTTGAAAAAAATAAGAAGATATTTGATTCCCCATATCAGCAGTTGTAAATCATAGGAAGAAAAATTCTATTGATTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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