Basic Information
VIS ID
TVIS44010848
Fusion event
HTLV-1-ABTB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
34207139/34185592 (Hg38)
End
34207139/34185592 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11E
Target gene
ABTB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-5p
Nearest miRNA
hsa-mir-210/Upstream/5708044; hsa-let-7a-2/Downstream/756245;
Nearest TSS
ENST00000527297/Upstream/38872; ENST00000528104/Downstream/56953;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/10883, chr11-CpG: 143/Downstream/171090
Upstream sequence
aggttgcatatgttacctctgaaacagtcaccctgcgagggagatatacttattagtctgcatttttacaaatgcagaaacagcctttgtagagggtagg
Downstream sequence
tcacatgtccaaggtgacatagctagACAAAGGTGATTAGTCTGGTTCTAAAAAACAACCATTCTGaatggtcactggaggctggagtggggttgggggg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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