Basic Information
VIS ID
TVIS44010849
Fusion event
HTLV-1-chr11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
34385504/34363957 (Hg38)
End
34385504/34363957 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11E
Nearest miRNA
hsa-mir-210/Upstream/5886409; hsa-let-7a-2/Downstream/577880;
Nearest TSS
ENST00000527297/Upstream/5949; ENST00000528104/Downstream/74968;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/4794, chr11-CpG: 58/Downstream/74661
Nearby gene
ABTB2(-5949) ;
Upstream sequence
GCTTCCATAGCTCCTCCTGCAAGGGTTAGAGAGTCACTAAGCAGGGAGCACAGAGATGATTTCAAAAGCATTGCTTGCTACATCGCGGTATTATGAAAAC
Downstream sequence
CATCTGGGTTGTTCTTTGGACACTTAACATAATATGCCTGAGAACAGGTGATAACTTAAATGAGTCGTTTTCAAATTGCCGAGTTGAGAAATCCCTTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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