Basic Information
VIS ID
TVIS44010850
Fusion event
HTLV-1-chr11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
35655090/35633542 (Hg38)
End
35655090/35633542 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA11E
Nearest miRNA
hsa-mir-1343/Upstream/691622; hsa-let-7a-2/Downstream/376556;
Nearest TSS
ENST00000527297/Upstream/13854; ENST00000525573/Downstream/23152;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/13605, chr11-CpG: 77/Downstream/29214
Nearby gene
FJX1(+12669) ;
Upstream sequence
tccgggaggcagaggttgcagtgagccaagatcgtgtcactgcactccagcctgggcaacagagtcagactctgtctaaaaaaaaaaaaaaaaaaGTTGC
Downstream sequence
TTCTTAACTATTTTGTCCAGCTGGAGAGACAGTTGGGGAGTGCCTGCAATCAGAAGTTCTGCAGCTGTCTGGGACCTGTCTATTCCAAGCTACGTACTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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