Basic Information
VIS ID
TVIS44010867
Fusion event
HTLV-1-TRPC6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
101388463/101517732 (Hg38)
End
101388463/101517732 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRPC6
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-10392/Upstream/5176206; hsa-let-7a-2/Downstream/2088;
Nearest TSS
ENST00000527297/Upstream/13642; ENST00000532529/Downstream/65771;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/388026, chr11-CpG: 114/Downstream/64894
Upstream sequence
TCCAGAAGGGTATTTAAAATTGTTTCAACCTTATCACTTTTCAAGTAACTGCTTTAAGTTTTTCTAGAGGAGGGaatatataaaaattattaattatata
Downstream sequence
gttaatttCTACCtgaagaaaccaagatacaaactaacttgcccaatgttaaacagctaCTTAGAACCCTCAGCTGTTAGATCATTTTTATTCCAAAATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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