Basic Information
VIS ID
TVIS44010881
Fusion event
HTLV-1-SSPN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
26362436/26209503 (Hg38)
End
26362436/26209503 (Hg38)
Orient
+
Location type
Intronic
Target gene
SSPN
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-765 ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4719 ; hsa-mir-4779 ; hsa-mir-296-3p ; hsa-mir-574-5p ; hsa-mir-297 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-378a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-3190-3p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6134 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-502-5p ; hsa-mir-3907 ; hsa-mir-4775 ; hsa-mir-590-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/335424; hsa-let-7i/Downstream/16114197;
Nearest TSS
ENST00000382841/Upstream/13830; ENST00000539552/Downstream/62319;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/13306, chr12-CpG: 101/Downstream/623046
Upstream sequence
tggaattgctgtcagatgtatatttagaatcttcttattctccctccatatttcttatcctgtctagtatgtttcatctctctttatctctctgtgctgt
Downstream sequence
atcttgggttattttctcagattttctggttcacttttcccttcttcatttaggtttaatctgccttttacttgtcctttgagtttttactgccagcaat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate