Basic Information
VIS ID
TVIS44010883
Fusion event
HTLV-1-FGD4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
32571500/32418566 (Hg38)
End
32571500/32418566 (Hg38)
Orient
+
Location type
Intronic
Target gene
FGD4
miRNAs that regulate target gene
hsa-mir-4487 ; hsa-mir-526b-5p ; hsa-mir-431-5p ; hsa-mir-6716-5p ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-1-3p ; hsa-mir-206 ; hsa-mir-613 ; hsa-mir-129-5p ; hsa-mir-3152-5p ; hsa-mir-4774-3p ; hsa-mir-3942-3p ; hsa-mir-6836-3p ; hsa-mir-5100 ; hsa-mir-4797-3p ; hsa-mir-545-5p ; hsa-mir-10b-3p ; hsa-mir-4266 ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-302f ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-335-3p ; hsa-mir-5096 ; hsa-mir-197-3p ; hsa-mir-4742-3p ; hsa-mir-339-5p ; hsa-mir-490-5p ; hsa-mir-7153-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/6544487; hsa-let-7i/Downstream/9905134;
Nearest TSS
ENST00000382841/Upstream/18710; ENST00000497153/Downstream/67406;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/18462, chr12-CpG: 72/Downstream/260630
Nearby gene
BICD1(+40359) ;
Upstream sequence
aggtaccaccttgatgatcttagataagatctggaagaattctctggattaccaagcagagactcttgttctcttcctttattttctcccaaacaaatgg
Downstream sequence
agtctctctctgtgctaaaccacctggaccttggggggtggggtgtcaccagcacaccgtggccaccacaactgggactgtaccggttcagacccgaagc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate