Basic Information
VIS ID
TVIS44010889
Fusion event
HTLV-1-ARID2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
46147531/45753748 (Hg38)
End
46147531/45753748 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARID2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-155-5p ; hsa-mir-424-3p ; hsa-mir-15b-5p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-374a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4474-3p ; hsa-mir-222-5p ; hsa-mir-4501 ; hsa-mir-545-5p ; hsa-mir-802 ; hsa-mir-203a-3p ; hsa-mir-194-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-127-5p ; hsa-mir-6071 ; hsa-mir-7160-5p ; hsa-mir-8077 ; hsa-mir-4663 ; hsa-mir-873-3p ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-3692-5p ; hsa-mir-93-3p ; hsa-mir-4329 ; hsa-mir-6728-3p ; hsa-mir-4499 ; hsa-mir-5584-3p ; hsa-mir-4277
Nearest miRNA
hsa-mir-1244-3/Upstream/3429889; hsa-let-7i/Downstream/1434064;
Nearest TSS
ENST00000382841/Upstream/23832; ENST00000480128/Downstream/83013;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/23076, chr12-CpG: 115/Downstream/236030
Nearest cancer related gene
ARID2(TSG, No orient, 0)
Upstream sequence
ctggagtgcaatagtgcgattgcgtctcactgcaacctttggtcaagcgatcctcccacctcagcctcccgaatagctgggactacaggcacgtgccacc
Downstream sequence
atgcctggctaatttttgtattttttgtagagacgaggtctccctgtgttgctcaggctggtctcgaactcctggactcaagcgatctgccctccttggc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate