Basic Information
VIS ID
TVIS44010902
Fusion event
HTLV-1-TMTC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
83510897/83117118 (Hg38)
End
83510897/83117118 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
TMTC2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-4470 ; hsa-mir-561-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6734-3p ; hsa-mir-6832-3p ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251
Nearest miRNA
hsa-let-7i/Upstream/1958657; hsa-mir-1178/Downstream/3627950;
Nearest TSS
ENST00000382841/Upstream/358563; ENST00000550279/Downstream/54472;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/429251, chr12-CpG: 17/Downstream/1794303
Upstream sequence
gggttttcctggtgttctcgtctagaatttttatactttcaggtcttaggttgaagtccttatccatgttgagttgatttttgtgtcaggtgagagttga
Downstream sequence
ggatccagttttattctcttacgtgtggctagccaattatcccagcaccatttgttgaacagggtgttctttccccactttgtttttgtttgctttgtct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate