Basic Information
VIS ID
TVIS44010906
Fusion event
HTLV-1-FGD6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
95499282/95105506 (Hg38)
End
95499282/95105506 (Hg38)
Orient
-
Location type
Intronic
Target gene
FGD6
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-6807-5p ; hsa-mir-135b-3p ; hsa-mir-8077 ; hsa-mir-7160-5p ; hsa-mir-4663 ; hsa-mir-508-3p ; hsa-mir-5186 ; hsa-mir-186-3p ; hsa-mir-4698 ; hsa-mir-150-5p ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1292-5p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-3918 ; hsa-mir-802 ; hsa-mir-8083 ; hsa-mir-6753-5p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-1289 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-6514-5p ; hsa-mir-3692-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-let-7i/Upstream/270993; hsa-mir-1178/Downstream/202914;
Nearest TSS
ENST00000382841/Upstream/13719; ENST00000551792/Downstream/11467;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/31818, chr12-CpG: 118/Downstream/111552
Upstream sequence
GCTGCTCTCAAAAGCTACAGGCCAGTCCCCACCATGACCATCAAACACTGCAAGTTCTTTATTTTCTGAATTCCCAAAACTGTAATTGTGCCTTTATAGT
Downstream sequence
GATATTTATTACTGTCTACTTTATAGGTATTTACGTGTAGTGTACTGTCTTCCCAACTAGTTGCTAAGTCCCTGGGGGAGGAAAGACAATAAGAATCATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate