Basic Information
VIS ID
TVIS44010916
Fusion event
HTLV-1-VSIG10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
118525322/118087517 (Hg38)
End
118525322/118087517 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
VSIG10
miRNAs that regulate target gene
hsa-mir-335-3p ; hsa-mir-5096 ; hsa-mir-421 ; hsa-mir-1306-5p ; hsa-mir-4709-5p ; hsa-mir-296-3p
Nearest miRNA
hsa-let-7i/Upstream/1659199; hsa-mir-1178/Downstream/1626117;
Nearest TSS
ENST00000382841/Upstream/5239; ENST00000542939/Downstream/15539;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/25849, chr12-CpG: 95/Downstream/15732
Upstream sequence
TTCTACAGCATCTCTGTCCATTCACACATCCCCAGCCACTTGCAGATAACAAACTGTCATATCTTGGAATTTGTTCCCCCTAGATTCCAAGGCCATGTTA
Downstream sequence
GAATGTTTCCAAATTGTTCTCCTTAAGAGAAGGAGGGggctgggcgaggtggttcatatctgtaagcccagcactttgggaggccaaggagggaagactg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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