Basic Information
VIS ID
TVIS44010921
Fusion event
HTLV-1-LATS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.11
Reference genome
GRCh37/hg19
Start
21604510/21030371 (Hg38)
End
21604510/21030371 (Hg38)
Orient
-
Location type
Intronic
Target gene
LATS2
miRNAs that regulate target gene
hsa-mir-31-5p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-93-5p ; hsa-mir-181b-5p ; hsa-mir-135b-3p ; hsa-mir-107 ; hsa-mir-25-3p ; hsa-mir-223-3p ; hsa-mir-6801-5p ; hsa-mir-4697-3p ; hsa-mir-1256 ; hsa-mir-202-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-545-5p ; hsa-mir-4257 ; hsa-mir-6847-5p ; hsa-mir-183-5p ; hsa-mir-1182 ; hsa-mir-1178-5p ; hsa-mir-562 ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-548m ; hsa-mir-510-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-494-3p ; hsa-mir-574-5p ; hsa-mir-4789-5p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-181c-5p ; hsa-mir-3605-3p ; hsa-mir-3659 ; hsa-mir-4468 ; hsa-mir-759 ; hsa-mir-802
Nearest miRNA
hsa-mir-4499/Upstream/596525; hsa-mir-1267/Downstream/3132045;
Nearest TSS
ENST00000623511/Upstream/7242; ENST00000485646/Downstream/31176;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/31050, chr13-CpG: 183/Downstream/30009
Nearest cancer related gene
LATS2(TSG, No orient, 0)
Upstream sequence
GTTAATTTTGAGTTACACTAGAAAAGGAACTCTGCTggccgggcgtggtggctcacacctgtaatcccagcactttgggaggccgacacgggtggatcac
Downstream sequence
gaggtcaggagatcgagaccatcctggccaacacggtgaaaccccgtctctactaaaaatgcacaaaattagccagccgtggtggcgggcgcctgtagtc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate